Somatropin Growth hormone (Eurohormones)
Human growth
hormone (Somatotropin) is produced in the body by the pituitary gland.
Before this happens, Growth Hormone Releasing Hormone (HGHRH) and
Somatostatin (SST) are released by the hypothalamus, and that determines
whether more or less HGH is produced by the pituitary. Many factors
influence the release of HGH, however, including nutrition and exercise.
Once it is released, Human Growth Hormone (HGH), which is also called
Somatotropin (STH) has many functions in the human body. HGH is a
protein that stimulates the body cells to increase both in size, as well
as undergo more rapid cell division than usual. In addition, it enhances
the movement of amino acids through cell membranes and also increases
the rate at which these cells convert these molecules into proteins.
Clearly, you can see that this would amount to an anabolic (muscle
building) effect in the human body. HGH also has the ability to cause
cells to decrease the normal rate at which they utilize carbohydrates,
and simultaneously increase the rate at which they use fats. Fat loss
and lean mass increases with HGH have been found at a dose as low as .
0.028 iu/kg/daily for 24 weeks, however, in our estimation, that would
be insufficient for a bodybuilder trying to gain muscle. Letīs use
0.028iu/kg as a working number; thatīs 2.8iu for a 100kg (220lbs)
bodybuilder. Thatīs certainly not unreasonable, and we would say that
that dose to 2x that dose is the range most bodybuilders and athletes
are finding their best results with. Also, that length of time used in
the study I just mentioned (24 weeks) is very typical of HGH use, and in
conversations with athletes who have used this compound, have told us
that they experience consistent results starting well after the
2-month-mark, and they tend to either run this stuff for 6 months at a
time, or year-round (if they have sufficient funds). Athlete is able to
consistently retain a shredded 6-7% body fat all year round with the
assistance of HGH, whether he is on steroids or off. Also it is noted
that athletes cardio (fast walking, for an hour a day) was much easier
while on HGH than when off, and certainly the research weīve done would
support his claim that sub maximal aerobic ability is improved with HGH
use.
How anabolic is this stuff? Well, even endurance athletes at rest were
observed in one study to be in an anabolic state. Yeah, so you can
basically run marathons and take this stuff, and still build some
muscle. Pretty impressive, right?
Growth Hormone is usually secreted in rhythmic pulses while you are
sleeping, as two peptides, HGHRH and Somatostatin (SST) are alternately
released. As you can guess, HGHRH (Growth Hormone Releasing Hormone) is
the one responsible for the Release of Growth Hormone (And who said
scientists have funny ways for naming things.
Growth hormone also has the ability to stimulate the production (or
reproduction, in the case of an injury) of cartilage. This, however,
requires the presence of a mediator substance, Somatomedin (IGF), which
is released from the liver in response to HGH, and the IGF, in turn,
actually promotes the growth of cartilage.
Although it requires IGF to actually grow new cartilage, HGH is directly
able to stimulate the elongation of bone tissue and HGH has also been
shown to elicit a positive effects on erythropoeisis, which is great for
both anabolism as well as endurance.
Remember the negative feedback loop we always tell you about? Well, of
course, your body has one which can stop the secretion of HGH, and it
involves IGF. When your liver receives secretes IGF-1, it sends a
message to both your Hypothalamus as well as your Pituitary to stop
producing HGH.
As you have probably guessed by now, your body produces the majority of
itīs HGH during your early years, when you are experiencing growth
spurts. As you get older, however, you just produce less of this stuff,
and its effects are much less pronounced. This was the driving force
behind the (always weird) life-extension crowd embracing HGH in the
early 90īs.
Side effects:
carpal tunnel syndrome, acromegaly (a thickening or growth of bones,
most noticeable in the feet, hands, and forehead), and enlarged organs.
Gynocomastia is also possible as a side effect of HGH use, as well as
Fluid retention (the later being initially pointed out to us by a female
colleague who had a pre-contest bodybuilder using HGH as part of his
contest prep).
Now for some
really interesting stuff:
Although HGH can easily produce very nice, high quality weight and
muscle gains, itīs a very poor compound for inducing strength gains.
Thatīs very counterintuitive, and certainly many strength athletes have
experienced great results in strength as well as muscle size and fat
loss from HGH. Generally, many studies have focused on HGH vs. HGH and
exercise, and without the exercise LBM increases but not usually maximum
voluntary strength output. It should also be noted that most athletes
utilizing HGH are using it in a "cocktail" with (at least) anabolic
steroids, and usually with IGF, thyroid meds, and other goodies such as
an Aromatase Inhibitor.
Letīs discuss
exactly why this is.
Most people who are taking the plunge into HGH use have reached a dead
end with their use of anabolics, and need to push through that wall. We
are sure youīve heard about the synergistic combination of using HGH
along with Anabolic Steroids, IGF, insulin and T3 (* usually synthroid,
a thyroid medication). The reason is that when these hormones are used
correctly together, theyīll produce a large amount of synergy, the
insulin is able to shuttle nutrients into your muscle, the thyroid
hormone increases your fat-burning capability, the IGF will cause muscle
growth as well as helping to grow new cartilage (thus preventing
injury), and the anabolic steroids like testosterone, specifically (in
addition to being anabolic) can increase IGF-1, in muscle tissue, and
maybe even increase your bodyīs ability to use it. Also, usually, an
increased amount of IGF usually tells your body to stop producing HGH,
but testosterone actually blunts this part of the Negative FeedBack Loop
and the addition of an Aromatase Inhibitor will also stop conversion of
testosterone into estrogen; estrogen reduces IGF levels. Finally, the
HGH does, well everything we just spent the last few pages telling you
about!
Thus, IGF, Testosterone (and of course other steroids), Insulin, thyroid
meds, and HGH will all combine to produce a pretty damned effective
fat-burning and muscle building cycle! You know what else? HGH is
virtually undetectable on any sort of currently used drug-screening
tests. HGH, Insulin, Thyroid meds, and IGF may also be used pretty
safely by those who may be subject to drug screening tests, or as a
non-HPTA suppressive "bridge" between cycles.
Finally, weīll tell you how weīd take HGH, personally. There was a study
done on continuous HGH use vs. every other day injections (ED vs. EOD
for the sake of brevity), with a equal total weekly dose. Although itīs
counterintuitive, every other day injections produced better total
growth in the kids in this (2 and 4 year long) study.
Shooting HGH
every other day more accurately replicates the pulsile frequency of HGH,
and thus gave better results for growth (height) deficient children, HGH
pulsatility is necessary for proper function of the HGH receptor. Dosing
in the EOD nature reduces incidence of any sort of withdrawal problems
associated with normal HGH use, including regression or retardation of
growth after cessation of therapy.
Therefore, we feel very comfortable speculating that the use of HGH in
this manner, which more closely simulates the natural secretion pattern
of it, allows the HGH receptors and the rest of the body to more
efficiently recover from it, and this will result in much more muscle
growth over time (although height was examined in the previous study).
Our recommendations therefore are 2 shots per day of 0.028iu/kg of
bodyweight, taken every other day, for a minimum of 3months, and
preferably for 2-3x that long, and preferably with the other synergistic
compounds weīve just taken a look at.
Effective Dose: 4 I.U., 2-4 times a week
Size:***
Strength:***
Side effects:*
Fat loss:**
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